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Netskope details CASB API support for Microsoft 365 Copilot

Source Decision Insights Coverage Published November 25, 2025 Companies 4
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4 companies named across 12 categories, one of 183 articles referencing Microsoft. Previous coverage: Netskope details updates to integrate with Microsoft Purview Copilot and Entra Suite (Nov 2025).

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Netskope has introduced Cloud Access Security Broker (CASB) Application Programming Interface (API) support for Microsoft 365 Copilot, enabling security administrators to monitor usage and enforce data protection and threat prevention policies on Copilot interactions. This development addresses key challenges in managing Artificial Intelligence (AI) integration security and compliance for enterprise IT and security teams.

Research overview

Netskope One's integration with Microsoft 365 Copilot provides organizations with tools to identify users licensed for Copilot and gain insight into their activities via application-level event tracking. This capability distinctly separates user prompts from AI-generated responses, facilitating precise monitoring and policy enforcement on specific interaction types.

Through dedicated dashboards and alert systems, administrators can track Data Loss Prevention (DLP) incidents and analyze historical Copilot interactions to support compliance audits, enhancing oversight on AI-driven data processing within enterprise environments.

Adherence to regulatory compliance

The integration supports enforcement of data compliance standards such as General Data Protection Regulation (GDPR), California Consumer Privacy Act (CCPA), and Health Insurance Portability and Accountability Act (HIPAA) by allowing organizations to monitor content uploaded to AI-managed folders in Microsoft OneDrive. Netskope One CASB API enables targeted data protection policies on content related to Copilot use, addressing sector-specific restrictions on data movement into AI applications.

Technical breakdown

Netskope’s DLP engines, equipped with standard compliance templates and extensive data identifiers, empower administrators to identify sensitive content in Copilot interactions and enforce remediation policies. This mechanism mitigates risks related to data exposure during AI interaction sequences.

Additional threat defense features include malware detection employing Machine Learning (ML), signature-based, and heuristic analyses, complemented by sandboxing techniques. These functions aim to prevent malicious content from being introduced via Copilot and provide near real-time alerts for security response teams.

Operational impact

The combined monitoring and enforcement capabilities facilitate more secure AI adoption by providing necessary control points across user activities within managed Copilot instances. This approach supports regulatory compliance and helps to reduce organizational risk tied to AI-related data handling.

By integrating Netskope One CASB API with Microsoft 365 Copilot, enterprises can maintain visibility and implement comprehensive data protection governance, ensuring security measures align with operational requirements for AI usage at scale.

This Blog Signals brief offers an objective summary of Netskope's recently announced extension to Microsoft 365 Copilot security, clarifying its relevance for enterprise decision-makers tasked with managing AI-related data protections and compliance obligations.

Blog post, originally published by Krishna Vasudevan at netskope.com.

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